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Product number: NC-0810

Capping B (Acetonitrile / Pyridine / N-methylimidazole, V / V / V = 50 : 30 : 20)

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2.5L, GL45 thread
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Capping B (Acetonitrile / Pyridine / N-methylimidazole, V / V / V = 50 : 30 : 20), Prod. No. NC-0810

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For each synthesis cycle, up to 1 to 2 % of free 5’-hydroxy groups remain after the phosphoramidite coupling step has been completed. By running a subsequent „Capping“ step using an anhydride, these free hydroxyl groups are converted to acetates and are hindered from further chain elongation and formation of long oligonucleotides with incorrect sequences. For optimal acetylation, a solution of acetic anhydride in Tetrahydrofuran or acetonitrile (Capping A) will be mixed in situ during reaction with a catalytic acting solution of N-methylimidazole (Capping B). Additives such as pyridine and lutidine function as mild bases to enhance the efficiency of the capping reaction.

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Hazard Classifications

Flammable liquid, Category 2 (Flam. Liq. 2)
Acute Toxicity, Category 4 (Acute Tox. 4)
Acute Toxicity, Category 3 (Acute Tox. 3)
Skin Corr. 1B

Hazard Statements

H225	Highly flammable liquid and vapour.
H302+H332	Harmful if swallowed or if inhaled.
H311	Toxic in contact with skin.
H314	Causes severe skin burns and eye damage.

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Material safety data sheet

Precautionairy Statements

P210	Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352	IF ON SKIN: Wash with plenty of water/…
P304+P340	IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P311	Call a POISON CENTER/doctor/….
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Signal Word

Danger

WGK

WGK 2

Storage Class Code

3 - Flammable liquids

ADR, RID (road and railroad)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

IATA-DGR (transport by air)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

IMDG-Code (transport by sea)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

Gefahreneinstufungen

Entzündbare Flüssigkeiten, Kategorie 2 (Flam. Liq. 2)
Akute Toxizität, Kategorie 4 (Acute Tox. 4)
Akute Toxizität, Kategorie 3 (Acute Tox. 3)
Skin Corr. 1B

Downloads

Material safety data sheet

Gefahrenhinweise - H-Sätze

H225	Flüssigkeit und Dampf leicht entzündbar.
H302+H332	Gesundheitsschädlich bei Verschlucken oder Einatmen.
H311	Giftig bei Hautkontakt.
H314	Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

Sicherheitshinweise - P-Sätze

P210	Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellen fernhalten. Nicht rauchen.
P261	Einatmen von Staub/Rauch/Gas/Nebel/Dampf/Aerosol vermeiden.
P302+P352	BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/… waschen.
P304+P340	BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P311	GIFTINFORMATIONSZENTRUM/Arzt/… anrufen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Signalwort

Gefahr

WGK

WGK 2

Lagerklasse

3 - Entzündliche flüssige Stoffe

ADR, RID (Strasse und Eisenbahn)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

IATA-DGR (Luftverkehr)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

IMDG (Seeschiffverkehr)

UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of N-Methylimidazole and Pyridine in Acetonitrile), 3(8), II

Material safety data sheet