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The phosphite triester formed in the coupling step can be converted to the corresponding phosphorothioate triester by treatment with 0.2 M solution of phenylacetyl disulfide (PADS) in acetonitrile and 3-picoline (V / V = 1 : 1). Typically, a 1.5-column volume of PADS solution is used, and sulphurization is complete within 3 minutes, at which time excess reagent is recovered from the reaction vessel by washing with acetonitrile.
An alternative sulfur-transfer reagent is 3-amino-1,2,4-dithiazole-5-thione (ADTT, also known as Xanthane Hydride) which is suitable for solid-phase synthesis.
Hazard Classifications
Acute Toxicity, Category 4 (Acute Tox. 4)
Respiratory/skin sensitisation, Category 1B (Skin Irrit. 1B)
Hazard Statements
| H302 | Harmful if swallowed. |
| H317 | May cause an allergic skin reaction. |
Precautionairy Statements
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P301+P312 | IF SWALLOWED: Call a POISON CENTER/doctor/… if you feel unwell. |
| P302+P352 | IF ON SKIN: Wash with plenty of water/… |
Signal Word
Warning
WGK
WGK 2
Storage Class Code
13 - Non-flammable solids in non-flammable package
ADR, RID (road and railroad)
Not dangerous goods.,
IATA-DGR (transport by air)
Not dangerous goods.,
IMDG-Code (transport by sea)
Not dangerous goods.,
Gefahreneinstufungen
Akute Toxizität, Kategorie 4 (Acute Tox. 4)
Sensibilisierung der Atemwege/Haut, Kategorie 1B (Skin Irrit. 1B)
Gefahrenhinweise - H-Sätze
| H302 | Gesundheitsschädlich bei Verschlucken. |
| H317 | Kann allergische Hautreaktionen verursachen. |
Sicherheitshinweise - P-Sätze
| P261 | Einatmen von Staub/Rauch/Gas/Nebel/Dampf/Aerosol vermeiden. |
| P280 | Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz/Gehörschutz/… tragen. |
| P301+P312 | BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/ … anrufen. |
| P302+P352 | BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/… waschen. |
Signalwort
Achtung
WGK
WGK 2
Lagerklasse
13 - Nicht brandgefährliche Feststoffe in nicht brandgefährlicher Verpackung
ADR, RID (Strasse und Eisenbahn)
Kein Gefahrgut.,
IATA-DGR (Luftverkehr)
Kein Gefahrgut.,
IMDG (Seeschiffverkehr)
Kein Gefahrgut.,