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Alkylation of the N3-position of thymidine by acrylnitrile, which is liberated during ß-elimination of the cyanoethyl group from the phosphates, is a well-known side reaction during simultaneous cleavage of the protecting groups and the oligonucleotide from the support.
This side reaction can be avoided by use of diethylamine or t-butylamine in acetonitrile for the ß-elimination. The oligonucleotide is subsequently cleaved from the support using any standard cleavage conditions.
Hazard Classifications
Flammable liquid, Category 2 (Flam. Liq. 2)
Acute Toxicity, Category 4 (Acute Tox. 4)
Skin Corr. 1A
Specific target organ toxicity - single exposure, Category 3 (STOT SE 3)
Hazard Statements
| H225 | Highly flammable liquid and vapour. |
| H302+H312+H332 | Harmful if swallowed, in contact with skin or if inhaled. |
| H314 | Causes severe skin burns and eye damage. |
| H335 | May cause respiratory irritation. |
Precautionairy Statements
| P210 | Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P303+P361+P353 | IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. |
| P304+P340 | IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
| P310 | Immediately call a POISON CENTER/doctor/… |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Signal Word
Danger
WGK
WGK 2
Storage Class Code
3 - Flammable liquids
ADR, RID (road and railroad)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IATA-DGR (transport by air)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IMDG-Code (transport by sea)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
Gefahreneinstufungen
Entzündbare Flüssigkeiten, Kategorie 2 (Flam. Liq. 2)
Akute Toxizität, Kategorie 4 (Acute Tox. 4)
Skin Corr. 1A
Spezifische Zielorgan-Toxizität (einmalige Exposition), Kategorie 3 (STOT SE 3)
Gefahrenhinweise - H-Sätze
| H225 | Flüssigkeit und Dampf leicht entzündbar. |
| H302+H312+H332 | Gesundheitsschädlich bei Verschlucken, Hautkontakt oder Einatmen. |
| H314 | Verursacht schwere Verätzungen der Haut und schwere Augenschäden. |
| H335 | Kann die Atemwege reizen. |
Sicherheitshinweise - P-Sätze
| P210 | Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellen fernhalten. Nicht rauchen. |
| P280 | Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz/Gehörschutz/… tragen. |
| P303+P361+P353 | BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen [oder duschen]. |
| P304+P340 | BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P310 | Sofort GIFTINFORMATIONSZENTRUM/Arzt/… anrufen. |
| P305+P351+P338 | BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
Signalwort
Gefahr
WGK
WGK 2
Lagerklasse
3 - Entzündliche flüssige Stoffe
ADR, RID (Strasse und Eisenbahn)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IATA-DGR (Luftverkehr)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IMDG (Seeschiffverkehr)
UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II