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SMART Chromatography™ CM Boost is packed with large cross-linked agarose beads, derivatized with carboxymethyl (CM) weak cation ligand. The resin has increased binding capacity due to more readily available ion exchange ligands localized on the bead surface. The gel can be used to purify biomolecules via their ion exchange ligands. It is specifically designed for SMART Chromatography™ ion exchange separation.
SMART Chromatography™ uses proprietary ZetaCell solid phases. These are based on large-particle highly cross-linked agarose, which is surface-modified to provide the desired binding functionality. The beads have been designed to allow cells and cell debris from the bioreactor to pass unhindered through the packed column bed.
SMART chromatography™ is covered by US Patent 11,325,104.